Rheumatoid arthritis and depression aninflammatoyperspective
- 256*791
-
0 次阅读
-
0 次下载
-
2020-12-09 18:24:21
微信
赏
支付宝
文档简介:
www.thelancet.com/psychiatryPublishedonlineOctober23,2018http://dx.doi.org/10.1016/S2215-0366(18)30255-41ReviewRheumatoidarthritisanddepression:aninflammatoryperspectiveLouisNerurkar,StefanSiebert,IainBMcInnes,JonathanCavanaghThecoexistenceofimmune-mediatedinflammatorydiseaseswithdepressionhaslongbeenrecognised.Datathatillustratetheintimateassociationsbetweenperipheralandbrainimmuneresponsesraisethepossibilityofsharedpathophysiologicalmechanisms.Theseassociationsincludethenegativeeffectsofproinflammatorycytokinesonmonoaminergicneurotransmission,neurotrophicfactors,andmeasuresofsynapticplasticity.Theevidencesupportingthisassociationisaccumulatingandincludesfindingsfromclinicaltrialsofimmunomodulatorytherapy,indicatingthattheseinterventionscanprovidebenefitstomentalhealthindependentofimprovementsinphysicaldiseasescores.InthisReview,weassessthisevidenceinrelationtorheumatoidarthritisanddepression,withafocusoninnateimmuneandmolecularresponsestoinflammation,anddiscussthechallengesofassessi
评论
发表评论