AComprehensiveAnalysisofGeneExpressionofXenobioticandEndogenousMetabolizingEnzymesandTransportersinR

4CurrentPharmaceuticalBiotechnology,2018,Vol.19,No.3Houetal.Fig.(2).Co-expressionofDMETsinelevenorgantypes.A.Topologicaloverlapmatrix(TOM)ofDMETgenes.Bothrowsandcolumnsweresortedbyhierarchicalclustering.Thecolorsspecifiedthestrengthofthepair-wisetopologicalconnections(yellow:notsignificantlyconnected;orange:highlyconnected).Geneswithhighlyconnectedwithinaclusterweredefinedasamodule.Eachmodulewasassignedauniquecoloridentifier(turquoise,blue,green,yellow,red,blackandbrown),withtheremaininggenesforgray;B.Expressionprofilesofgenesinturquoise,blue,green,yellow,red,blackandbrownmodules.Relativeexpressionforgeneswasstandardizedasz-score(meanzeroandstandarddeviationofone)atgenelevel.Standardizedexpressionlevelswerecolorcoded,withredforhighexpressionlevelsandgreenforlowexpressionlevel.TopfiveenrichedGeneOntologiestermswerelistednexttoeachmoduleonright.Ad,adrenal;Br,brain;He,heart;Ki,kidney;Li,liver;Lu,lung;Mu,skeletalmuscle;Sp,spleen;Te,testis;Th,thymus;Ut,uterus.computed.Conversionintoamatrix