您好,欢迎访问知识创客N-你的免费文库

上传文档

当前位置:首页 > 论文下载 > 国外论文 > Orchestrating Opiate-Associated Memories in Thalamic Circuits

Orchestrating Opiate-Associated Memories in Thalamic Circuits

  • 256*791
  • 0 次阅读
  • 0 次下载
  • 2020-12-10 11:33:01
二扫码支付 微信
二扫码支付 支付宝

还剩... 页未读,继续阅读

免费阅读已结束,点击付费阅读剩下 ...

¥ 0 元,已有0人购买

免费阅读

阅读已结束,您可以下载文档离线阅读

¥ 0 元,已有0人下载

免费下载
文档简介:

exposuretoevenasmallamountofdrugitselfismorepotentintriggeringrelapselongaftercessationofchronicdruguse(Bos-sertetal.,2013;Shahametal.,2003;Venniroetal.,2016).Impor-tantly,transientinhibitionofthePVT/NAcpathwaycompletelypreventedmorphine-primed(10mg/kg,i.p.)relapseat4or14daysofabstinence(Figure2E)buthadnoeffectonmorphine-inducedincreaseoflocomotion(Figure2F).Lastly,whenthepathwaywasinhibitedinanovelenvironment,themiceshowedarobustCPPwhentested1daylater(Figure2G),indicatingthatmemoryretrievalisrequiredforPVT/NAcpathwayinhibitioncauseddisruptionofmorphineCPP.Together,theseresultsrevealthatactivityinthePVT/NAcpathwayisrequiredforboththeretrievalandmaintenanceofopiate-associatedmemoriesandsubstantiatethePVT/NAcpathwayasapotenttargetforrelapseprevention.Accordingtomemoryreconsolidationtheory,retrievalcanputmemoriesintoalabilestate,inwhichtheybecomemoresuscep-tibletochange(Naderetal.,2000).Thelabilestageofretrievedmemoriesisatime-dependentprocess(<6hafterretrieval)calledreconsolidation,w

256*791
256*791
  • 1206

    文档
  • 66

    金币
Ta的主页 发私信

1206篇文档

评论

发表评论
< /16 > 免费下载 ¥ 0 元

Powered by DS文库

Copyright © 知识创客N-你的免费文库 All Rights Reserved. 蜀ICP备2020030266号-1
×
保存成功