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Schisandra chinensis extract ameliorates nonalcoholic fatty liver via inhibition of

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  • 2020-12-10 11:24:17
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3Nonalcoholicfattyliverdisease(NAFLD),characterizedbyexcessivelipidaccumulationintheliver,isanimportanthepaticmanifestationofmetabolicdisorder.TheprevalenceofNAFLDishighlyincreasingandaffectsapproximately30%oftheworldpopulation(SchattenbergandSchuppan,2011).Hepaticsteatosis,definedasover-accumulationoftriglycerideinhepatocytes,isaprerequisitestepofNAFLD.NAFLDentailsvarioushepaticdiseasesrangingfromsimplesteatosistosteatohepatitis,fibrosis,cirrhosis,andhepatocarcinoma(FarrelandLarter,2006;PosticandGiard,2008).Therefore,developmentofagentsthatcanalleviatehepaticlipidaccumulationmaybeatherapeuticapproachtotreatmentofhepaticdisordersassociatedwithNAFLD.Theendoplasmicreticulum(ER)playsaroleinfoldingandprocessingofnascentsecretedandmembraneprotein,synthesisoflipidsandsterolsandstorageofintracellularCa2+(RonandWalter,2007).AnumberofstimulithatinduceERdisturbance,suchasglucosedeprivation,calciumdepletion,viralinfection,hypoxia,andoxidativestress,inhibitfoldingcapacityoftheER,leadingtoaccumula

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