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The effect of aging on the pluripotential capacity and regenerative potential of human periodontal l

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TheeffectofagingonthepluripotentialcapacityandregenerativepotentialofhumanperiodontalligamentstemcellsJingZhanga,b,c,1,YingAna,b,1,Li-NaGaoa,b,c,1,Yong-JieZhangb,c,YanJinb,c,**,Fa-MingChena,c,*aDepartmentofPeriodontology&OralMedicine,SchoolofStomatology,FourthMilitaryMedicalUniversity,Xi’an,ChinabResearchandDevelopmentCenterforTissueEngineering,FourthMilitaryMedicalUniversity,Xi’an,ChinacTranslationalResearchTeam,SchoolofStomatology,FourthMilitaryMedicalUniversity,Xi’an,ChinaarticleinfoArticlehistory:Received27May2012Accepted17June2012Availableonline11July2012Keywords:AgingPeriodontalligamentstemcellsCytotherapyPeriodontaltissueengineeringRegenerativemedicineabstractMultipotentpostnatalstemcellscanbeisolatedfromhumanperiodontalligaments(PDLs)andhavethepotentialforlarge-scaleexpansion,offeringareliablecellsourceforclinicaluseinperiodontalregen-erativetherapies.However,theeffectsofagingonthemesenchymalstemcell(MSC)propertiesofthesecellsremainundefined.Theaimsofthisstudyweretoisolateandcharacterizetheperiodontalligamentstemcells(PDLSCs)derivedfromhumanimpactedthirdmolarsofdonorsofdifferentagesandtocomparetheirpluripotentialcapacityandregenerativepotential.PDLtissueswereobtainedfrom90surgicallyextractedthirdmolarsanddividedintofourgroupsaccordingtothedonor’sage.Foreachgroup,thecolony-formingability,proliferativecapacity,migratorypotential,cellsurfaceantigens,differentiationability,alkalinephosphataseactivity,andgeneexpressionofthePDLSCswerecontras-tivelyevaluatedandquantifiedf

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