您好，欢迎访问知识创客N-免费论文下载

文档
  • 文档
  • 专题
  • 悬赏
  • 文章
  • 问答
上传文档

文档分类

当前位置：首页 > 学术论文 > 国外论文 > Applying high-dimensional single-cell

Applying high-dimensional single-cell

二扫码支付 微信
赏
二扫码支付 支付宝

还剩... 页未读，继续阅读

免费阅读已结束，点击付费阅读剩下 ... 页

ⓞ 0 知识点，已有0人购买

免费阅读

阅读已结束，您可以下载文档离线阅读

ⓞ 0 知识点，已有0人下载

免费下载
文档简介：

Tumoursareacomplexmixtureofmalignant,immuneandstromalcells,whichoftenhavesubstantiallevelsofintratumourandintertumourheterogeneity.Thetumourmicroenvironment(TME)comprisesanamalgamoftumour-promotingandanti-tumoursignalsthatareabletomodulatetumourgrowthandinfluencetumourevolution.Bulkgenomicandtranscriptomicanalyseshaveprovidedvaluableinsightsintotheseprocesses,buttheaveragingofsignalsfromlargenumbersofcellsrenderedbythesemethodsoftenobscuresspecificsubpopulationsand/orcellularstates.Indeed,rareanduniquecellularsubtypesorstatesthatmightbeinstrumentalindiseasebiology,suchaspotential‘cancerstemcells’orimmunecellscrucialforatherapeuticresponse,mightnotbedetectedinbulkanalysesderivedbyaveragingdatafrommillionsofcells.Forcancerimmunotherapy,andthislimitationreducesthepowertodistinguishthediversityofcellularsubtypesandstatespresentintheTME.Breakthroughsinsequencingtechnologies,cell-isolatingmicrofluidicsandanalyticalbioinformaticshaveledtoarapidproliferationofsingle-cellanalysismethodologies,andhavebeenreviewedextensivelyelsewhere3–6.Thesetechniquesenablethedetectionofmanyanalytesatsingle-cellresolutioninalargenumberofcells(initiallyafewhundred,butnowthousandstohundredsofthousandsofcells)inanincreasinglycost-effectivemanner.Theconcomitantblossomingoftheavailabilityofbioinformatictoolshasenabledresearcherstointerrogatethemassivedatasetsprovidedbysuchmethodsinordertoexploitthecovariatepowerattheheartofsingle-celldata,visualizethediversityofcellularsubtypesandelucidatetheinteractionsbe

文档达人
文档达人

  • 8641

    文档

  • 15

    金币
Ta的主页 发私信

共8641篇文档

相关文档

Applying high-dimensional single-cell 0
Facile 3D cell culture protocol based on photocurable hydrogels 0
Three-dimensional numerical investigations of 0
Factor Models for High-Dimensional Tensor Time Series 0
Technological challenges in the environmental applications of MXenes and future outlook Ihsanullah I 1
ResearchonanewschemeofLCC-HVDClineprotection 0
High-Intensity Focused Ultrasound Effectively Reduces Adipose Tissue. Seminars in Cutaneous Medicine 0
基于激光点云和倾斜影像的三维建模方法研究 0
High-energy 2 µm pulsed vortex beam excitation from a Q-switched TmLuYAG laser 0
Single-pass continuous-flow leach test of PNL 76-68 glass some selected Bead Leach I results 0

相关搜索

Applying high dimensional single cell

评论

发表评论
< /13 > 免费下载 ⓞ 0 知识点
扫描二维码
关注官方微信

联系我们

  • 电话 : 18081164280

    邮箱 : 2335771074@qq.com

    Q Q : 2335771074

    地址 : 成都市金牛区花照壁

Powered by DS文库

Copyright © 知识创客N-免费论文下载 All Rights Reserved. 蜀ICP备2020030266号-1
×
取消确定
保存成功
$urls = array( 'http://www.example.com/1.html', 'http://www.example.com/2.html', ); $api = 'http://data.zz.baidu.com/urls?site=https://www.fabuzhijia.cn&token=SLuZ3R4dqpKJoC8K'; $ch = curl_init(); $options = array( CURLOPT_URL => $api, CURLOPT_POST => true, CURLOPT_RETURNTRANSFER => true, CURLOPT_POSTFIELDS => implode("\n", $urls), CURLOPT_HTTPHEADER => array('Content-Type: text/plain'), ); curl_setopt_array($ch, $options); $result = curl_exec($ch); echo $result;