A Diet‐Dependent Microbiota Profile Associated with Incident Type 2 Diabetes From the CORDIOPREV Stu

RESEARCHARTICLEwww.mnf-journal.comADiet-DependentMicrobiotaProfileAssociatedwithIncidentType2Diabetes:FromtheCORDIOPREVStudyAntonioCamargo,*CristinaVals-Delgado,JuanF.Alcala-Diaz,AlejandroVillasanta-Gonzalez,FranciscoGomez-Delgado,CarmenHaro,AnaLeon-Acuña,MagdalenaP.Cardelo,JoseD.Torres-Peña,IpekGuler,MariaM.Malagon,JoseM.Ordovas,PabloPerez-Martinez,JavierDelgado-Lista,andJoseLopez-Miranda*Scope:Thedifferencesbetweenthebaselinegutmicrobiotaofpatientswhodevelopedtype2diabetes(T2D)consumingalow-fat(LF)oraMediterranean(Med)dietareexploredandriskscoresaredevelopedtopredicttheindividualriskofdevelopingT2DassociatedwiththeconsumptionofLForMeddiet.MethodsandResults:AllthepatientsfromtheCORDIOPREVstudywithoutT2Datbaseline(n=462)whosefecalsampleareavailable,areincluded.Gutmicrobiotaisanalyzedby16SsequencingandtheriskofT2Dafteramedianfollow-upof60monthsassessedbyCoxanalysis.Lineardiscriminantanalysiseffectsize(LEfSe)analysisshowsadifferentbaselinegutmicrobiotainpatientswhodevelopedT2DconsumingLFandMeddiets.AhigherabundanceofParaprevotella,andlowerGammaproteobacteriaandB.uniformisareassociatedwithT2DriskwhenanLFdietisconsumed.Incontrast,higherabundancesofSaccharibacteria,Betaproteobacteria,andPrevotellaareassociatedwithT2DriskwhenaMeddietisconsumed.Conclusion:TheresultssuggestthatdifferentinteractionsbetweenthemicrobiomeanddietarypatternsmaypartiallydeterminetheriskofT2Ddevelopment,whichmaybeusedforselectingpersonalizeddietarymodelstopreventT2D.Dr.A.Camargo,C.Vals-Delgado,Dr.J.F.Alcala-Diaz