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Adsorption of Antisense Oligonucleotides Targeting Malarial Topoisomerase II on Cationic Nanoemulsio

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SendOrdersforReprintstoreprints@benthamscience.netCurrentTopicsinMedicinalChemistry,2014,14,1161-11711161AdsorptionofAntisenseOligonucleotidesTargetingMalarialTopoi-someraseIIonCationicNanoemulsionsOptimizedbyaFullFactorialDesignFernandaBruxel1,2,AmélieBochot2,DirneteDiel1,LuisaWild1,EdisonL.S.Carvalho3,SandrineCojean4,PhilippeM.Loiseau4,EliasFattal2andHelderF.Teixeira1,*1ProgramadePós-graduaçãoemCiênciasFarmacêuticasdaUniversidadeFederaldoRioGrandedoSul(UFRGS),Av.Ipiranga2752,90610-000PortoAlegre,Brazil;2UniversitéParis-Sud,CNRSUMR8612,Physico-chimie-Phar-macotechnie-Biopharmacie,FacultédePharmacie,5rueJeanBaptisteClément,Châtenay-Malabry,92296,France;3ProgramadePós-graduaçãoemProdutosBioativoseBiociênciasdaUniversidadeFederaldoRiodeJaneiro(UFRJ)campusMacaé,RiodeJaneiro,Brazil;4ChimiothérapieAntiparasitaire,UMR8076CNRS,UnivParis-Sud,5RueJean-BaptisteClément,92296Châtenay-Malabry,FranceAbstract:Cationicnanoemulsionshavebeenrecentlyconsideredaspotentialdeliverysystemsforoligonucleotides(ON)targetingPlasmodiumfalciparumtopoisomeraseIIgene.Thisstudyisaimingtoselectthebestcompositionofnanoemul-sionsintendedtoONadsorptionbymeansofa23fullfactorialdesign.Basedontheirphysicochemicalproperties,twoformulationswereselectedforfurtherstudies,bothcomposedbymediumchaintriglycerides,egg-lecithin,andeitheroleylamine(OA)or1,2-dioleoyl-3-trimethylammonium-propane(DOTAP).AdsorptionisothermsofphosphodiesterorphosphorothioateONontheoptimizednanoemulsionswereobtained(ultrafiltration/centrifugation

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