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A New Labdane Diterpene from the Aerial Parts of

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SHORTREPORTThearticlewaspublishedbyACGPublicationshttp://www.acgpubs.org/journal/records-of-natural-productsMonth-Month2020EISSN:1307-6167DOI:http://doi.org/10.25135/rnp.175.20.02.1559Rec.Nat.Prod.14:5(2020)378-382ANewLabdaneDiterpenefromtheAerialPartsofChloranthusserratusMingZhao1,GangChen2,TingtingLin2*andYuLu1*1XuyiPeople'sHospital,Xuyi,211700,P.R.China2JiangxiProvincialPeople'sHospital,Nanchang330006,P.R.China(ReceivedFebruary20,2020;RevisedMarch17,2020;AcceptedMarch25,2020)Abstract:Anewlabdanediterpene(1)andfiveknowncompounds(26)wereisolatedfromtheaerialpartsofChloranthusserratus.Thegrossstructureofcompound1wasresolvedbyNMRandHRESIMSdata.Theabsoluteconfigurationof1wasdeterminedbycomparingCDspectrumandspecificrotationswiththoseoftheco-isolatedknownanalogue2.Theknowncompoundswereidentifiedtobeagathicacid(2),altechromoneA(3),chlorajapolideF(4),shizukanolide(5),andchloranthalactoneE(6)bycomparingtheNMRdatawiththoseintheliterature.AllcompoundswereevaluatedfortheirinhibitionsagainstNOproductioninLPS-activatedRAW264.7macrophages,compounds2and6showedmoderateinhibitionswithIC50valuesof45.21.2and35.30.9M.Keywords:Chloranthusserratus;labdanediterpene;inhibitions;NOproduction.©2020ACGPublications.Allrightsreserved.1.PlantSourceTheaerialpartofChloranthusserratuswerecollectedinNovember2014inGuangdongProvince,P.R.China.IdentityofthespecieswasidentifiedbyProf.LinJiangofSchoolofPharmaceuticalSciences,SunYat-senUniversity,Guangzhou.Thevoucherspecimen(accessionnumber:SYXS201411)wasdep

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