Orchestrating Opiate-Associated Memories in

ArticleOrchestratingOpiate-AssociatedMemoriesinThalamicCircuitsGraphicalAbstractHighlightsdThePVT/CeApathwayassociatesopiaterewardtotheenvironmentdManipulationofthePVT/NAcorNAc/LHpathwaypreventsopiate-primedrelapsedRepeatedopiateuseenhancesfeedforwardinhibitionfromPVTtotheNAc/LHpathwaydiDISCO+mappingrevealsbrain-widenetworksforstoringopiate-associatedmemoriesAuthorsPiperC.Keyes,ElizaL.Adams,ZijunChen,...,MarcTessier-Lavigne,YingjieZhu,XiaokeChenCorrespondenceyj.zhu1@siat.ac.cn(Y.Z.),xkchen@stanford.edu(X.C.)InBriefKeyesetal.establishthePVTasakeynodeintheopiate-associatedmemorynetwork.ThePVT/CeApathwayassociatesopiaterewardtotheenvironment,whereastransientmanipulationofthePVT/NAcpathwayoritsdownstreamNAc/LHpathwayduringretrievalerasesopiate-associatedmemoryandcausesenduringprotectionagainstrelapsetoopioiduse.Keyesetal.,2020,Neuron107,1113–1123September23,2020ª2020ElsevierInc.https://doi.org/10.1016/j.neuron.2020.06.028ll