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Dysregulated autophagy in COPD A pathogenic process to be deciphered

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ContentslistsavailableatScienceDirectPharmacologicalResearchjournalhomepage:www.elsevier.com/locate/yphrsReviewDysregulatedautophagyinCOPD:ApathogenicprocesstobedecipheredW.S.DanielTana,Han-MingShenb,c,W.S.FredWonga,d,e,⁎aDepartmentofPharmacology,YongLooLinSchoolofMedicine,NationalUniversityHealthSystem,16MedicalDrive,117600,SingaporebDepartmentofPhysiology,YongLooLinSchoolofMedicine,NationalUniversityofSingapore,2MedicalDrive,117597,SingaporecNUSGraduateSchoolforIntegrativeSciencesandEngineering,NationalUniversityofSingapore,28MedicalDrive,117456,SingaporedImmunologyProgram,LifeScienceInstitute,NationalUniversityofSingapore,28MedicalDrive,117456,SingaporeeSingapore-HUJAllianceforResearchandEnterprise(SHARE),NationalUniversityofSingapore,1CREATEWay,InnovationWing,138602,SingaporeARTICLEINFOKeywords:AutophagyLC3AggresomeEmphysemaMitophagyCiliophagyOxidativestressABSTRACTAutophagyisanevolutionaryconservedprocessthatisresponsibleformaintainingcellularhomeostasisthroughlysosome-dependentdegradationofdamagedproteins,lipidandorganelles.Whenautophagyisdysregulatedbyfactorssuchascigarettesmoking,environmentalinsultsandageing,itcanleadtoformationofaggresome-bodiesandenhancedproductionofreactiveoxygenspecies(ROS),ofwhichcontributetothepathogenesisofchronicobstructivepulmonarydisease(COPD).ThisreviewwillaimtodecipherthepathogenicprocessofautophagythatisdysregulatedbythevariousriskfactorsofCOPD,leadingtoeithercelldeathorsenescenceandCOPDprogression.Itwillalsocoverpotentialtherapeuticsth

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