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Antioxidant Effocf of Carvcdllol and motoprolol in Congostlve Heart Failure

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JA('CFchni:lO+I~.~)~.'tR~l'RA(:l~,Or~d1~gA11:15[~AntloxklantEffectofCan,'~lllolandMetoprololInCongseUveHeartFailureM.L.Kukin,J,Kalman,RH.Charnoy,D,K,Levy,C,Buchholz-Varley,ON,O~mpo,C,Eng.Cardiova.~Jt~rtns~fute,MountSinaiSctx~ofMe~ne,NY.NY.USAAlthoughtheant~x~antpro!~ffiasofCeCile!(C)I~vebeonmeasur~lmv~f~oincelli~el~ttor~,l!loyhavenotbeenshow~mvn/oinhas~fa+t~rel~llentsItI~~!vevmuslydereo~ratedthatlhlObe~ifur~Cacidrea~iv~=ubslan,~'e+(T1BAR5),wl~:harematkemofIq~lpefoxldallonandomid~tivestress,ame/evatndinCItFpalltmtse~mparedtoco~trols.TBAh~~tsoircreit~mwlthwOr~u~a~ngNYHAclass.Todate,themhavebeennodire~~rls0~sofCar<lMetopmtol(M)inaCHFpupu!abenWerandomlya~ig~4~d56palients(ol~nlabel)toMorC,BaselineevaluationinchJdedeff~tv~fra¢tio~tEF).sVm~omscore(SS),QOLlnck~x,6mmwalk.mVO~,~ndTBARSasmeasuredby~rophofometryintheplasma,/~.blocke~wasg~adualtyl~traledtoatart]elcloseof25mgb~d150mgb~litwl:.85kg)foebothCandMBackg~ndtherapyconsistedelA~orACE1195%).dlgoMinand~Llrellcs.ellhe56pta(meanage58)43¢o~pleted6monthsoflong-termtherapy.Thereware41menand15women;etmlogy:~1iselmm~,30~liopathi¢,5valvulartt~thNYHAclass!LqlI/tV:11/39~.Theentiregroup(C&M)showeds~gnd~=ant,parallel.~pmvements(p0.01)inEF118TO22%),SS1103to7-5),CIOL(5~to37),walk(1152to1247feel),aP~l,~/C~{I~.~to120ml,'kg,*m~n~,(byAN~VA)withnobetweengroup~ttemnce.TBARSconoentreben(ng,~ml)atweeks-2.0(baselineaveraged)andMo~tl~4&6wdhCdeclinedfrem5L~to44to43andwff'hMfrom48to4.6Io3.9.P=00002foro~,rallchangeovert~membothgroupsw;thnobetweengr

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