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Phagosomes, fatty acids and tuberculosis

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NEWSANDVIEWS776NATURECELLBIOLOGYVOLUME5|NUMBER9|SEPTEMBER2003corticallybound,populationofmicrotubulesintheregionofthefurrowobservedbyCanmanetal.Thesefactorswouldmostprobablyincludeproteinsknowntolocalizeto,andmediateformationof,inter-zonalmicrotubulebundles,includingacomplexcontainingahomologueoftheplus-end-directedkinesinMKLP-1andaRho-GAPtermedcentralspindlin12(reviewedinref.6),andaproteincomplexthatcontainstheAuroraBkinase,Bir1andINCENP(reviewedinref.13).Membersofthissecondgroupofproteinshavebeentermedchromosomalpassengers,becausetheyfirstassociatewithchromosomesandthenrelocalizetothecentresoftheinter-zonalmicrotubulebundlesattheonsetofanaphase.Theideathatchromosomescarryfactorsthatstimulatefurrowingisappealingbecausealthoughchromosomesarenotabsolutelyessentialforfurrowing3,14,15,manyolderobservationssuggestthatthepresenceofchromatinpromotesfurrowingressionandcompletion(reviewedinref.5).Recentdataindicatingthatthechromosomalpas-sengerproteinaurora-Bcanbedeliveredtothecleavagefurrowb

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