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Activating Macrophage-Mediated Cancer Immunotherapy

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2020-12-10 16:11:04

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©2020Wiley-VCHGmbH2004853(2of9)www.advmat.dewww.advancedsciencenews.comextremelyimportantinpavingthewayforclinicalapplicationofCD47-SIRPαimmunotherapy.RecentadvancesincancerimmunologyhaverevealedthatthecompromisedefficacyofCD47-SIRPαblockadesmightbecausedbyimmunosuppressivetumormicroenvironment(TME).[11,12]Inparticular,cancercellssecretcolonystimulatingfactors,whichpolarizetumor-associatedmacrophages(TAMs)towardM2phenotype.[11,12]M2TAMscanrecruitregulatoryT-cells(Tregs)tohinderCD47-blockade-inducedT-cellimmuneactivation.[2,13,14]Therefore,repolarizingTAMsfromprotu-morigenicM2phenotypetoantitumorM1onemayregaintheantitumorimmunityofCD47blockades.Moreover,thelimitedefficacyandsideeffectsmaybeowingtononspecificaccu-mulationofsystemicallyinfusedCD47antagonistsinnormaltissues.[10,12]Thus,itwouldbeidealforCD47-SIRPα-mediatedantitumorimmunotherapytoconcentrateontheTMEwhilstavoidingoff-targetimmuneactivationinothersites.Rapidprogressinnanotechnologyandmaterialsscience,espe-ciallyinfunctionaliz

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